I made a quick tutorial awhile ago:
The software always reverts to the last profile edited - so if 'Desktop' was your last then it will revert to that when the software starts. It can be useful but also a pain if you forget to set your default profile as the last one edited.
Best way (IMHO) is to create 2 basic profiles - 1st Person and 3rd Person - and set them up for whatever keys you want. Then change the game key bindings to match the mouse. If you then find a game that you want to do something special with (like a deep click zoom) thencreate a sub=profile and just programme that one function.